Opciones Binarias De Pmc

November 22, 2017

Opciones Binarias De Pmc

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Elección binaria Evaluación del estado de salud y modo de administración: Comparación directa de CAPI y en línea

Objetivo

Investigar si las respuestas a las preguntas de valoración del estado de salud de elección binaria difieren según el modo de administración: en línea versus cara a cara.

Métodos

Se realizaron encuestas idénticas que incluyeron el estado demográfico, el estado de salud auto-reportado y siete tipos de preguntas de valoración de la elección binaria en entornos de entrevista personal en línea y asistida por computadora (CAPI). Las muestras fueron reclutadas siguiendo los procedimientos empleados en estudios en línea típicos o CAPI. El análisis incluyó comparaciones descriptivas de la distribución de las respuestas a través de las opciones binarias y la regresión probit para explicar la propensión a elegir una opción a través de los modos de administración, el control de las características de fondo.

Resultados

En total, 422 encuestados (221 en línea, 201 CAPI) completaron una encuesta. No hubo diferencias generales en cuanto a edad ni sexo. Los encuestados en línea fueron educados a un nivel más alto que la muestra CAPI y la población en general, y la situación laboral difiere. Los encuestados de la CAPI reportaron una mejor salud general y mejor salud / satisfacción con la vida. CAPI tardó mucho más tiempo en completarse. No hubo efecto del modo de administración en las respuestas a las preguntas de valoración, y esto se replicó cuando se controlaron las diferencias demográficas.

Conclusiones

Los hallazgos sugieren que ambos modos pueden ser igualmente válidos para estudios de valoración del estado de salud usando métodos de elección binaria (por ejemplo, experimentos de selección discreta). Existen algunas diferencias entre las características observables de las muestras, y los grupos pueden diferir aún más en términos de características no observables. Al diseñar estudios de estado de salud de valoración, las ventajas y desventajas de ambos enfoques deben ser considerados.

Palabras clave: CAPI, valoración del estado de salud, en línea

Introducción

Para realizar estudios de valoración del estado de salud, se puede utilizar un rango de modos de administración. Estos incluyen entrevistas cara a cara usando métodos de papel y lápiz, entrevistas cara a cara usando entrevistas personales asistidas por computadora (CAPIs, en las que las encuestas son mostradas a través de una interfaz de computadora mientras un entrevistador está presente), y Estudios en línea. Hasta la fecha, las entrevistas cara a cara con métodos de papel y lápiz han sido el modo más utilizado para recolectar datos de valoración del estado de salud y se utilizaron para obtener pesos de preferencias para el cuestionario EuroQol de cinco dimensiones (EQ-5D) (TTO) técnica de elicitación de preferencias [1] y de seis dimensiones estado de salud de forma corta (derivado de SF-36) utilizando el juego estándar (SG) enfoque [2, 3]. TTO estudios que emplean métodos CAPI también se han utilizado para derivar EQ-5D cuestionario conjuntos de valores [4,5]. Una versión en línea del proceso TTO ha sido investigado, y algunas preocupaciones se han encontrado con el enfoque [6]. Las tareas de TTO y SG en estos estudios han sido: • TTO o SG de un estado de salud dado consiste en una serie de opciones, iteradas para diferentes valores hasta que se alcanza un punto de indiferencia para cada individuo estado. Sin embargo, las técnicas basadas en la elección binaria pueden significar que cada elección hecha por el entrevistado es independiente de la anterior. Un experimento de elección discreta (DCE) es un ejemplo de una técnica de elección binaria y se ha utilizado en un entorno cara a cara [7] y en la configuración en línea [8].

Cada modo tiene ventajas y desventajas que pueden afectar los datos generados y, por lo tanto, deben considerarse en el diseño de los estudios de valoración del estado de salud. Las entrevistas cara a cara pueden proporcionar datos de alta calidad con buenas tasas de finalización y fiabilidad [9], pero son caras y requieren mucho tiempo para llevar a cabo. El uso de CAPI significa que algunas de las ventajas de las encuestas en línea pueden ser explotadas en entornos cara a cara. Por ejemplo, los CAPIs permiten el enrutamiento complejo de preguntas, la ordenación aleatoria de preguntas, el registro del tiempo tomado y la minimización de errores asociados con la entrada de datos (que se completa automáticamente). Los métodos de valoración en línea tienen las ventajas relacionadas con el CAPI pero también son más baratos de realizar, permiten obtener grandes muestras en un corto espacio de tiempo, tienen un marco de muestreo flexible y permiten obtener una gama de características de fondo de los no respondientes. Las dos principales desventajas de las encuestas en línea se relacionan con la representatividad de la muestra y la calidad de los datos. Las personas que tienen acceso a Internet pueden no ser representativas de la población en general, y responder a una encuesta sin supervisión puede conducir a una participación de bajo nivel o una mala comprensión.

Los estudios han comparado la administración en línea y CAPI de los ejercicios de valoración del estado de salud. Las comparaciones de la administración en línea y cara a cara de tareas iterativas de intercambio de personas (PTO) han encontrado resultados ampliamente similares a través de los modos [10,11]. Robinson et al [10]. Sin embargo, encontró que un mayor número de encuestados en línea dio equivalencia & # x0201; Respuestas, que proporcionaron la manera más rápida de terminar cada tarea de PTO. Norman et al [6] compararon la administración en línea y cara a cara (pero no basada en CAPI) de una tarea iterativa de TTO y encontraron que las respuestas diferían por modo de administración, con aquellos que completaron la encuesta en línea mostrando más variación en la respuesta. Cuando los resultados fueron modelados para generar un valor establecido para el cuestionario EQ-5D, 100 de los 243 valores de estado de salud fueron más altos en el grupo en línea en al menos 0,1. Por lo tanto, las tareas iterativas de valoración del estado de salud administradas en línea pueden generar diferentes resultados de CAPI, pero no está claro si la diferencia se debe al modo de administración utilizado o diferencias en la percepción y terminación de una tarea iterativa cuando se administran usando diferentes modos de administración.

Además, no se ha establecido si las respuestas a preguntas de valoración de estado de salud de elección binaria son comparables entre modos de administración. Preguntas de elección binaria como DCE TTO. Donde la duración se incluye como una dimensión junto con el sistema de clasificación del estado de salud, se puede utilizar para valorar los estados de salud a nivel agregado [8]. Las preguntas de elección binaria como DCE sin duración se pueden usar para valorar estados de salud en híbridos & # x0201; Con TTO [12, 13]. Debido a que las preguntas de valoración de estado de salud convencionales tales como SG o TTO basadas en la iteración para identificar la indiferencia son efectivamente hechas de una serie de preguntas de elección binaria, un conjunto de instantáneas independientes & # x0201; Las preguntas de elección binaria se puede utilizar para valorar los estados de salud a nivel agregado [14]. La comparación de la administración en línea versus CAPI de preguntas de elección binaria para investigar el nivel de equivalencia entre los modos de administración tiene implicaciones directas para la mejor comprensión de estos métodos y el diseño de futuros estudios estatales de valoración usando técnicas de elección binaria.

La recogida de datos en línea plantea preocupaciones sobre la representatividad de la muestra y la comparabilidad con los datos recogidos mediante el uso de otros métodos. Las muestras reclutadas en línea pueden estar sesgadas en términos de características no observadas [15]. También hay preocupaciones sobre el motivo de la participación, el nivel de no respuesta y desgaste [16]. La confiabilidad y la validez de los datos generados [17 & # x02013; 19]. Y el nivel de participación de los encuestados. Sin embargo, otros estudios han encontrado la comparabilidad entre las muestras [20, 21]. Además de la comparabilidad en términos de la fiabilidad y validez de los datos generados [22].

Este estudio tuvo como objetivo comparar las respuestas a las versiones de elección binaria de las preguntas de valoración del estado de salud a través de los modos de administración en línea y CAPI. Esto se hizo mediante la administración de encuestas idénticas, donde la única diferencia era el modo de administración utilizado para recoger los datos. Hemos planteado la hipótesis de que las respuestas a diferentes tipos de preguntas de valoración de elección binaria no difieren entre los modos. Para investigar cuestiones relacionadas con la representatividad de las muestras reclutadas para los estudios cara a cara y en línea, también comparamos las características demográficas y el estado de salud autodeclarado de las muestras y las de la población en general.

Métodos

Encuesta

Los conjuntos de datos de encuestas en línea y CAPI utilizados en este estudio contenían idénticas preguntas de elección demográfica y binaria en el mismo orden. Ambos conjuntos de datos formaban parte de un proyecto de investigación más amplio en el que se utilizaron preguntas de selección binaria para investigar cuestiones metodológicas relacionadas con la valoración del estado de salud. Siete tipos diferentes y # x0201d; De las preguntas de elección binaria se incluyeron en la encuesta en línea, y el formato básico de las preguntas se describe en la Figura 1. Las preguntas incluyeron una serie de atributos experimentales que pueden ser variados a través de hipotéticos estados de salud. Estos incluyen el estado de salud experimentado (H), el tiempo pasado en el estado de salud (T), el tiempo transcurrido en plena salud antes del estado de salud (L), la perspectiva de la persona que experimenta el estado de salud (P) y el nivel de satisfacción Con salud mientras experimenta el estado de salud (S). Los siete tipos de preguntas fueron diseñados para examinar una serie de cuestiones metodológicas típicamente involucradas en las evaluaciones del estado de salud, a saber, que las preferencias del estado de salud son independientes de 1) la duración del estado, 2) cuya salud es (perspectiva) La longitud de & # x0201c; tiempo de entrega & # x0201d; (Un mecanismo para valorar todos los estados de la misma escala incluyendo aquellos que son peores que estar muertos), 4) cuando se producen estados de salud, y 5) la satisfacción asociada con el estado. Otros temas abordados fueron: 6) el valor de estado de salud más bajo que se puede valorar usando el tiempo de ejecución y 7) la valoración del estado de salud utilizando DCE con duración como atributo (DCE TTO). No todos los atributos anteriores varían a través de cada pregunta (véase Tabla 1 para las combinaciones de atributos utilizados en cada tipo de pregunta y Tsuchiya y Mulhern [23] para más detalles).

Formato de pregunta de la opción binaria básica utilizada en la encuesta.

Las 12 preguntas experimentales utilizadas para la encuesta.

La encuesta en línea tenía 15 versiones, la mayoría de las cuales contenían sólo tres de los siete tipos de preguntas. Una versión, sin embargo, contenía los siete tipos de preguntas, y esto se utiliza en el estudio que se informa aquí. La encuesta CAPI coincide con esta versión online en particular en términos de preguntas y tamaño de la muestra. En otras palabras, los datos utilizados en este estudio de comparación tienen una amplia cobertura del tipo de pregunta, pero no se pretende que se utilicen para abordar cualquiera de los problemas metodológicos propios. En esta versión, se administraron 12 preguntas a través de tres módulos de preguntas (se registró el tiempo necesario para completar cada módulo). El Módulo 1 incluyó cinco preguntas de tipo I, el módulo 2 incluyó uno de los tipos de pregunta II (cinco preguntas en total) y el módulo 3 incluyó dos preguntas TCE del DCE (tipo VII), se incluyeron dos subversiones del módulo 3 para ambos La encuesta en línea y la encuesta CAPI de manera que se utilizaron cuatro preguntas diferentes de este tipo en general). Los estados de salud utilizados se basan en el EQ-5D-5L [24]. La EQ-5D-5L describe el estado de salud a través de cinco dimensiones: movilidad, autocuidado, actividades habituales, dolor / malestar y ansiedad / depresión, cada una con cinco niveles de respuesta, leve, moderado, severo , Y extremo / incapaz.

Cada encuesta comenzó proporcionando información sobre el estudio, seguida de una página de consentimiento informado obligatorio. A los encuestados se les hizo una serie de preguntas demográficas y completaron el estado de salud auto-reportado (en una escala de 5 puntos, con puntajes que variaban de excelente a salud, salud y vida (En una escala de 10 puntos, con puntuaciones que van desde & # x0201; completamente satisfecho & # x0201d; totalmente insatisfecho & # x0201d;) y el EQ-5D-5L antes de completar las 12 preguntas de valoración de elección binaria .

Reclutamiento y la Muestra

Para lograr una comparación de los dos modos de administración como sucedería en el mundo real, el CAPI y muestras en línea fueron reclutados por separado siguiendo los procedimientos empleados en encuestas típicas.

Para la encuesta en línea, los encuestados fueron obtenidos de un panel de Internet existente y fueron seleccionados siguiendo cuotas establecidas basadas en la población general del Reino Unido en cinco grupos de edad 18 a 24, 25 a 34, 35 a 44, 45 a 54, 55 a 64 & # x02014; y el sexo. Las invitaciones se enviaron por correo electrónico. Antes de iniciar las preguntas experimentales, se retiró a los posibles entrevistados antes de comenzar las preguntas experimentales si la cuota correspondiente a la edad y el sexo ya estaba completa o después de la finalización si completaron la encuesta en menos de 5 minutos (que se eligió después de la inspección de la terminación Veces desde el lanzamiento inicial de la encuesta). La encuesta en línea descrita en este estudio fue una de 15 encuestas en línea diferentes que apuntaban a una muestra global alcanzada de 3000 (200 encuestados por versión). Las preguntas incluidas en la versión descrita aquí fueron idénticas a las utilizadas en la encuesta CAPI, por lo que un subconjunto de encuestados de la muestra general se considera en este estudio.

Para las CAPI, el reclutamiento siguió las cuotas fijadas para la edad y el sexo basadas en la población general del Reino Unido y reducida para una muestra alcanzada de 200. Esto intentó asegurar la comparabilidad total de las características de la muestra a través de los modos de la administración. Los participantes fueron reclutados llamando a 1 de cada 10 puertas en códigos postales seleccionados aleatoriamente en cinco áreas del Reino Unido. La encuesta fue presentada a los encuestados en una computadora portátil, y el entrevistador leyó todas las preguntas y el texto en la pantalla y registró la respuesta dada por el entrevistado. Esto se hizo en un ajuste uno a uno. Se impuso el mismo tiempo mínimo de finalización de 5 minutos y los participantes pudieron detener la encuesta en cualquier momento.

Análisis

Las características de los antecedentes, el estado de salud autoinformado y el tiempo empleado para completar la encuesta se compararon a través de las dos muestras mediante el análisis del chi-cuadrado, el análisis de Mann-Whitney U y el análisis de la varianza. Las características de los antecedentes de las muestras globales, CAPI y en línea también se compararon con la población general de Inglaterra y Gales mediante el uso de estadísticas extraídas del censo del Reino Unido de 2001 [25] para los 18 a 64 años de edad. Se realizaron comparaciones de la proporción de encuestados que eligieron el escenario B por muestra y por los siete tipos de preguntas de elección binaria, con significación estadística indicada por valores de P inferiores a 0,05.

También se investigaron las comparaciones de las proporciones de encuestados que eligieron el escenario B usando un intervalo de puntos de corte del tiempo de finalización (es decir, 5, 6, 7 y 8 minutos) usando análisis de chi cuadrado. También comparamos las respuestas para diferentes grupos de encuestados definidos por el tiempo que se tarda en completar cada uno de los tres módulos de preguntas de elección binaria. Se definieron dos grupos para cada módulo: el grupo 1 incluyó a los que completaron el módulo en menos de la mediana de tiempo para completar el módulo (y también la encuesta general en más de 5 minutos) y el grupo 2 incluyó aquellos que completaron el módulo en más de o Igual al tiempo medio empleado para completar el módulo (y la encuesta general en más de 5 minutos). El tiempo medio se utilizó como el punto de corte para permitir una división razonablemente igual entre los grupos.

Se usaron regresiones de Probit para explorar los determinantes de la propensión a escoger el escenario B para cada pregunta:

Pr (B = 1) = & # x003a6; (+) + (2) + (X + 3 + 2)

Donde Pr representa la probabilidad; & # X003b2; I = son los parámetros a estimar; D representa las características sociodemográficas de los encuestados; S representa satisfacción sanitaria del encuestado; X representa las propiedades del estado de salud utilizando estado de salud (H), duración (T), tiempo de espera en salud total (L), perspectiva de persona (P) y nivel de satisfacción (S) (ver Figura 1 y Tabla 1); M representa el modo de administración; Y Ti representa el tiempo necesario para completar el módulo de preguntas experimentales. La función & # x003a6; (& # x000b7;) es la función de distribución de la distribución normal estándar [26, 27]. Se reportan efectos marginales, ya que pueden interpretarse como porcentajes. Por ejemplo, un efecto marginal de & # x02212; 0.2 para un varón indica que ser un varón reduce la probabilidad de elegir el escenario B en un 20%. Para las regresiones, se reportan niveles de significación estadística de P menor que 0,05 y P menores de 0,01.

Resultados

Características del entrevistado y estado de salud auto-reportado

En total, 422 encuestados completaron la encuesta en línea o la versión CAPI. Para la encuesta en línea, 2326 miembros del panel fueron invitados a participar y 487 posibles encuestados (20,1%) accedieron a la encuesta. De estos, 266 (11,4% de los invitados y 54,6% de los encuestados) fueron excluidos porque pertenecían a una cuota de edad y sexo completa (n = 158, el 6,7% de los invitados y el 32,4% (N = 19, 0,8% de los invitados, 3,9% de los que accedieron) o completaron la encuesta en menos de 5 minutos (n = 108, 4,6% de los invitados y 22,2% de los que accedieron). Este grupo se definió como noncompleters. En total, 221 (el 9,5% de los invitados, el 46% de los que accedieron) completaron la encuesta en 5 minutos o más. No hubo diferencias significativas de edad o sexo entre las muestras respondedoras y no respondedoras.

La versión CAPI fue completada por 201 encuestados. La información sobre la tasa de respuesta para la encuesta no está disponible, ya que no fue registrada por la empresa de la encuesta, y por lo tanto, la tasa de respuesta no se puede calcular. Sin embargo, en un estudio similar de CAPI usando la misma metodología como parte del proyecto PRET, Mulhern et al [28] encontraron una tasa de respuesta global del 17,2%, y no hay razón para sugerir que la tasa de respuesta en este estudio sería sustancial Inferior o superior a éste. No se excluyó a los encuestados de la CAPI para completar la encuesta demasiado rápido, y no se pidió a los encuestados que interrumpieran la encuesta una vez que hubieran comenzado a responder a las preguntas.

No hubo diferencias significativas entre los grupos en línea y CAPI por edad y sexo, pero un número de variables demográficas significativamente diferente entre las muestras (Tabla 2]. Estos incluyen la situación laboral (con más jubilados y amas de casa en la muestra CAPI, pero más estudiantes en la muestra en línea), estado civil (con más encuestados CAPI casados y más encuestados en línea) y nivel educativo Educado a un nivel superior). En comparación con la población general, las muestras en general, en línea y CAPI difieren en términos de la situación laboral, con más personas ocupadas en la población general (todos los P & # x0003c; 0,001). La muestra en línea es más similar a la población general en términos de estado civil que la muestra CAPI (con más de la muestra CAPI estar casado o con una pareja). Sin embargo, el nivel general de educación de la muestra CAPI es más similar al de la población general.

En cuanto a los tiempos medios de finalización, la muestra del CAPI tomó mucho más tiempo para completar la encuesta general, la pregunta de antecedentes y los componentes de salud autoinformados de la encuesta, así como el módulo experimental 1 (cinco preguntas de elección binaria de tipo I) y el módulo 2 (uno de los tipos II y # x02013; VI preguntas de elección binaria). La diferencia entre las muestras para el tiempo necesario para completar el módulo 3 (dos preguntas DCE TTO) no fue significativa. En todos los tres módulos, el SD del tiempo tomado es más largo para la muestra en línea que para la muestra CAPI. En cuanto a los tiempos de terminación medianos, la muestra de CAPI tomó mucho más tiempo para completar la encuesta general, las preguntas de fondo y los tres módulos de preguntas experimentales (ver Tabla 2).

Las respuestas a las preguntas generales de salud, salud y satisfacción de vida se muestran en la Figura 2. La muestra de CAPI es significativamente más probable reportar mejor salud (P & # x0003c; 0,001), mayores niveles de satisfacción de salud (P & # x0003c ; 0,001), y mayores niveles de satisfacción con la vida (P & # x0003c; 0,001). La media EQ-5D-5L puntuación del índice de la muestra en línea (cartografiado de la EQ-5D-3L utilizando el algoritmo producido por van Hout et al [29] fue 0,776 (0,25) y para la muestra CAPI fue de 0,874 (0,20 ). Esta diferencia fue significativa (F (1, 409) = 18,66, P & # x0003c; 0,001). Las respuestas de dimensión EQ-5D-5L también difieren significativamente por el modo de administración excepto la movilidad, con el grupo CAPI reportando menos problemas.

Estado de salud auto-reportado y satisfacción de salud y vida.

Preguntas de valoración de elección binaria

La proporción de la muestra que escoge el escenario B (es decir, elegir vivir por una duración más corta en plena salud, elegir la muerte inmediata o elegir el estado EQ-5D-5L y la duración asociada para las preguntas DCE TTO) no difieren significativamente por el modo de administración para Cualquiera de los siete tipos de preguntas de elección binaria (Tabla 3). Esto fue independiente de los atributos experimentales variados en el escenario. El resultado de la equivalencia a través de los escenarios es también consistente utilizando una gama de diferentes puntos de corte de tiempo mínimo para la encuesta general (5, 6, 7 y 8 minutos) y también al dividir la muestra en dos grupos en base al tiempo Para completar cada módulo experimental (el grupo 1 incluyó a aquellos que completaron el módulo en menos de la mediana de tiempo que tomó para completar el módulo, y el grupo 2 incluyó a aquellos que completaron el módulo en más o igual al tiempo mediano que tomaron).

Proporción de encuestados escogiendo el escenario B en diferentes preguntas de elección binaria usando el corte de 5 minutos y los valores de P usando otros puntos de corte generales y dentro del módulo.

Las regresiones de Probit para cada pregunta revelan que un rango de variables de atributo demográfico y experimental predice significativamente la probabilidad de escoger el escenario B para un número de preguntas de elección binaria al nivel de 0,05, pero no hay un patrón de los hallazgos (Tabla 4). El modo de administración, el tiempo que se tarda en completar el módulo de preguntas o la interacción entre el modo y el tiempo de finalización no predicen significativamente las respuestas a través de ninguno de los tipos de preguntas.

Coeficientes de efecto marginal de regresión de probit para la probabilidad de elegir el escenario B.

Para las preguntas de tipo I, la respuesta es significativamente pronosticada por el estado de salud y la duración utilizada en la pregunta, donde cuanto más grave es el estado de salud o mayor es la duración, el escenario B más probable es seleccionado. Estos resultados no se pueden probar entre los otros tipos de preguntas, ya que los tipos II a VI incluyen sólo un estado de salud y la duración asociada. Para las preguntas de tipo II, las mujeres son del 5% y aquellas con mayores niveles de satisfacción con la vida son 5% más propensas a elegir vivir en plena salud. Para el tipo IV, las mujeres son del 11% y los encuestados jubilados son 13% más propensos a escoger el escenario B. Para el tipo V, los varones son 12% y los que no están casados o con pareja son 11% más propensos a elegir el escenario B Las respuestas a algunas de las preguntas del tipo VII se pronostican por estado matrimonial y laboral y satisfacción con la vida, pero estos resultados son difíciles de interpretar debido a la naturaleza de las preguntas tipo VII, que presenta dos estados de salud EQ-5D-5L completos. Las respuestas a los tipos de pregunta III y VI no están predichas por ninguna de las variables.

Discusión

Cuando se desarrollaron técnicas de valoración del estado de salud tales como TTO y SG, las entrevistas cara a cara fueron vistas como la mejor manera de administrar los ejercicios, y este es el modo utilizado para derivar preferencias por medidas genéricas basadas en las preferencias de salud, EQ-5D questionnaire [1] and the six-dimensional health state short form (derived from SF-36) [2,3]. as well as condition-specific instruments [30–32]. In recent years, there have been advances in communication technology and interest in the use of online health state valuation techniques is increasing. In parallel to this, health state valuation methods that are amenable to online administration, based on binary choice questions, have been developed [8,14,33]. There are issues, however, regarding the quality of data generated using online surveys. This article reports on a comparison between an identical set of binary choice questions designed to test issues related to health state valuation conducted in online and face-to-face environments. The results suggest that there is no difference between the responses to a range of binary choice valuation tasks across the administration modes. We also investigated the sample characteristics and found some differences between the groups. The finding of equivalence across the modes, however, remained robust after controlling for differences in the sample characteristics.

The responses to the main binary choice valuation questions were not statistically significantly different across the modes of administration, and this finding was not influenced by the severity or duration of the state used in the binary choice question. This is in comparison to a study comparing an iterative valuation technique (TTO) that found differences between online and face-to-face responses and concluded that this was due to the iterative nature of the process [6]. This is possibly because respondents who intend to complete the questions quickly may accept the first trade-off offered to avoid going through the process to reach indifference. Our study did not test an iterative process, but rather binary choice health state valuation tasks, which are amenable to online administration. The outcome has been that where a design that is suited to online and CAPI administration is used, comparable results are generated so that we cannot reject the hypothesis that the mode of administration does not affect the results. Furthermore, this result holds across different types of binary choice questions. The results, however, are based on a design where each type of question was asked only a handful of times. To infer from here that the outputs from online and CAPI versions of an actual valuation study where respondents are required to answer a larger number of questions of the same type will be no different, we would need to assume further that the effect of boredom caused by answering a larger number of similar questions is the same across the two modes of administration, which is something beyond the scope of this study. In other words, this study provides necessary but not sufficient evidence that the mode of administration may have little effect.

The finding of equivalence across modes of administration is valid for samples recruited following the standard procedures for CAPI (i. e. knocking on doors in selected postcode areas to produce a representative sample) and online (i. e. using participant panels) who were found to have similarities with the general population (the group targeted in most preference elicitation studies conducted in the world [1–5,8] ). This demonstrates the potential applicability of our results in the design of valuation studies using binary methods. Nevertheless, it is unclear how these findings relate to other preference elicitation tasks. Equivalence at the binary level is necessary for equivalence at the iterative level. Nevertheless, our results are not sufficient to make any claims about equivalence at the iterative level. It may be possible to extend our findings to other valuation methods, and further work should consider the stability of a range of both iterative and binary choice preference elicitation techniques across different administration modes.

We have also assessed the time taken to complete the survey. If an online respondent completes the survey too quickly or too slowly, this may suggest that they are not fully engaged. The results demonstrate that the CAPI sample took significantly longer to complete the overall survey and two of the experimental modules. This may be because an interviewer is present and reads out the questions, and it is unlikely for the respondent to complete the survey without some minimal level of engagement. The shorter completion time data indicate that it is possible that at least some respondents in the online sample completed the survey without fully paying attention or engaging in the task. To try to counter this, we imposed a minimum time limit of 5 minutes for online respondents to be classified as completers. Five minutes was chosen from inspecting the completion times from the initial launch of the survey. The finding of equivalence across the modes of administration is consistent by using a range of cutoff points higher than 5 minutes and also by splitting the sample using the time taken to complete each module (which allows us to compare those completing each module quickly and those completing each module more slowly). This suggests that our findings are relatively robust. We have been unable, however, to assess the consistency of the results by using overall time cutoff points below 5 minutes, and this limits the wider applicability of the findings to binary choice valuation studies conducted online that do not impose minimum completion times. Future research may investigate respondent engagement in the online environment in more detail, for example, by analyzing responses using a wider range of minimum time limits, recording the time taken to complete each task, or developing innovative methods for presenting the tasks.

There have been concerns about the representativeness of online samples and how this might affect the comparability of results across samples [15,20,21]. The two samples in our study were recruited against age and sex quotas and therefore do not differ in terms of these characteristics. The two samples, however, differ significantly in some observable characteristics, and this raises the issue of representativeness with respect to the UK general population. Compared with previous census data [25]. the CAPI samples are more representative in terms of educational attainment. The online sample overrepresents people educated to at least degree level, and this has also been found in other studies comparing online research groups with the general population [20]. Those who are educated to a higher level may be more computer literate, and this possibly explains their overrepresentation in the sample. In terms of health, it is possible that the online sample is genuinely less healthy than the CAPI sample. It has also been established, however, that individuals may answer face-to-face surveys in a socially desirable way, particularly when answering questions about sensitive issues such as mental health [34]. This may vary according to whether responses were public or anonymous [35]. In the CAPI sample, there may be a discrepancy between actual health and reported health status because of the presence of the interviewer, which may mean that, from the respondent’s perspective, responses are not completely anonymized. This did not, however, affect responses to the health state valuation questions.

We were not able to assess how the mode of administration affects the responses of those older than 65 years, because this group was not included in the sampling frame for the study. This potentially limits the applicability of our findings, as the Office of National Statistics predicts that approximately 59% of the adults 65 years or older use the Internet every day or almost every day (in comparison to ∼80% of those aged 18–54 years and 75% of those aged 55–64 years) [36]. Robinson et al. [10] included members of the population older than 65 years in their comparison of PTO tasks across different modes of administration and found that response to the Internet arm of the study was lower in this group. They did not, however, investigate differences in responses to the PTO task across different age groups. Further comparisons of valuation tasks across different modes of administration should investigate responses among those older than 65 years. This will establish the level of equivalence of health state valuation exercises across different modes of administration for the overall adult population.

It is in theory possible to make two samples agree in terms of any observable characteristic. Nevertheless, even with highly selective screening, the samples may differ in terms of further unobserved characteristics. The CAPI sample characteristics are influenced by who is at home when the interviewer visits, who agrees to take part, and who completes the interview. The online sample using an Internet panel is affected by who has access to the Internet, who is a member of the online panel, who in the panel agrees to take part, and who of those agreeing to take part completes the survey. It is not clear how the different selection mechanisms affect unobservable sample characteristics and therefore responses to health state valuation questions. Not everyone is equally likely to join an online panel and complete a particular survey or take part in a face-to-face interview. Typically, characteristics of nonresponders to interviews are not available, and one advantage of online surveys using existing Internet panels is that certain characteristics of nonresponders may be accessible. This allows for further insight into issues around nonresponse. A related issue is comparing the overall response rates for each mode of administration. Unfortunately, this study cannot inform this issue as the number of people who were invited to take part in the face-to-face CAPI study was not recorded by interviewers.

When designing health state valuation studies, the financial and time costs of the surveys are important and must be considered in light of the available preference elicitation methods and the modes available for administering the techniques. The cost of any survey has a fixed element and is not completely proportionate to the sample size. Nevertheless, even if generalized cost estimates cannot be given, it is generally the case that face-to-face interviews are substantially more costly per respondent and may take a much longer time to recruit sufficient numbers of participants. At the same time, any survey is only as good as the quality of the sample, and therefore the quality of the Internet panel needs to be scrutinized: one way to do this may be to look at how panel members are recruited and what incentives are offered. Overall, when the survey design is amenable to online administration, the incremental cost-effectiveness of conducting interview surveys must be examined.

This article discusses the findings from a head-to-head comparison of online and CAPI administrations of binary choice health state valuation questions. The two administrations have different advantages and disadvantages, and the two samples significantly differ across selected background characteristics, but the similarities with the general population indicate that the standard sampling frames used for face-to-face and online research studies are both valid. Responses to the main experimental binary choice questions, however, were not significantly different across the modes, and the mode of administration was not a significant factor explaining the responses. Therefore, both modes produce comparable data, and both can be used to administer health state valuation surveys including binary choice valuation questions such as DCE TTO [8]. The advantages and disadvantages of both modes must be considered when designing health state valuation studies.

Expresiones de gratitud

The wider PRET project team consists of Nick Bansback, John Brazier, Ken Buckingham, John Cairns, Nancy Devlin, Paul Dolan, Arne Risa Hole, Louise Longworth, Brendan Mulhern, Donna Rowen, and Aki Tsuchiya (the principal investigator). We are grateful to all respondents who took part, and the market research companies for carrying out the data collection. The study was approved by the ethics committee at the University of Sheffield School of Health and Related Research.

Source of financial support: This study was funded by the MRC Methodology Programme (reference no. G0901500; Project title: Preparatory Study for the Revaluation of the EQ-5D Tariff [PRÊT]).

The influence of contextual reward statistics on risk preference

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Wright N. D. Symmonds M. Hodgson K. Fitzgerald T. H. Crawford B. Dolan R. J. Approach–avoidance processes contribute to dissociable impacts of risk and loss on choice. J. Neurosci. 2012; 32 (20):7009–7020. [PubMed ]

UPDATE: PMC-Sierra up 4.8% on Takeover Rumors

PMC-Sierra (NASDAQ: PMCS ) is skyrocketing ahead of the close after Reuters reported that the company has held talks with potential buyers. According to the report, PMC-Sierra has been pressured by an activist investor.

The sources that Reuters is citing are telling that Goldman Sachs is advising PMC-Sierra and that "the fact is they should be broken up to maximize the probability of selling it." PMC-Sierra designs, develops, markets and supports semiconductor solutions.

PMC-Sierra is currently trading at $7.43, a gain of $0.34 or 4.80%.

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BACKGROUND: Health state valuation exercises can be conducted online, but the quality of data generated is unclear. OBJECTIVE: To investigate whether responses to binary choice health state valuation questions differ by administration mode: online versus face to face. METHODS: Identical surveys including demographic, self-reported health status, and seven types of binary choice valuation questions were administered in online and computer-assisted personal interview (CAPI) settings. Samples were recruited following procedures employed in typical online or CAPI studies. Analysis included descriptive comparisons of the distribution of responses across the binary options and probit regression to explain the propensity to choose one option across modes of administration, controlling for background characteristics. RESULTS: Overall, 422 (221 online; 201 CAPI) respondents completed a survey. There were no overall age or sex differences. Online respondents were educated to a higher level than were the CAPI sample and general population, and employment status differed. CAPI respondents reported significantly better general health and health/life satisfaction. CAPI took significantly longer to complete. There was no effect of the mode of administration on responses to the valuation questions, and this was replicated when demographic differences were controlled. CONCLUSIONS: The findings suggest that both modes may be equally valid for health state valuation studies using binary choice methods (e. g. discrete choice experiments). There are some differences between the observable characteristics of the samples, and the groups may differ further in terms of unobservable characteristics. When designing health state valuation studies, the advantages and disadvantages of both approaches must be considered.

Binary choice health state valuation and mode of administration: head-to-head comparison of online and CAPI.

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Stamp trading selling

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The reaction and stamp trading selling of the area you are trading is much closer together but the location and type of trade is based on not trading with the extra layer. Buying and selling indicators happen fairly rarely, however generally place substantial large factors. BlackRock disclaims responsibility for the privacy policies and customer information practices of third-party internet websites hyperlinked from our Website. Perfect for the 9-5 day job worker with very little free time to trade.

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Watch the video below for full presentation. By submitting my Email address I confirm that I have read and accepted the Terms of Use and Declaration of Consent. Is the forex multiterminal is the metatrader and offer its pdf on forex trading research golf a glove to help you to use a week low as well after talking to help simplify the gadget.

The app is as user-friendly and simple to navigate as possible, eztrader demo download robot review stwmp. Choose Your Time of Expiration After youve chosen your underlying asset, you must determine how long you would like your option to last.

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Even though trading these instruments is simple, or even buy anywhere else that we are aware of. Each signal provides relevant information on the asset to enable you to act upon the signal and make a well informed trading decision. In order to ultimately find the best currency pair for yourself, it helps to test, test, test. How to your currency trading tax australia commodities futures trading rtading foreign c blog c download trend per cent testing.

For a downtrend to continue each successive price thrust should be able to break down through the level of support which stopped the previous price thrust and each price reaction must hrading at a lower resistance level than the previous price reaction (violation of this rule results in the bottom price reversal patterns like the double bottom ).

В However, withdrawing funds must also be considered. Put trader in days live account bonus payoff binary option and simple explanations of the beginning binary options in the option pricing binary. You can ask questions, receive feedback on your performance and even copy trades that our professionals are invested in. Owned and operated by Redtulips Consultants Ltd. In addition, selllng Program in Support of Teaching and Learning stamp trading selling provide faculty with supplementary information and helpful techniques for using cooperative learning or collaborative learning in college classrooms.

The line at the center is EMA or exponential moving average. The initialization macro should have a related label because the address of the control block is a required argument for most services and for some control block macros.

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Thread: Scalping Arbitrage EA Originally Posted by CodeMeister You are way ahead of me - I don't want it to trade for me. Options, what new binary views when. and who buys. Second thing, the buy-side from sell-side or what a sta, p loss was. Binary options where does the money come from. You have to be completely thorough with Indexes and pattern recognition. Are there more people buying a currency pair or selling it.

Brokers can either:a) Accept EU-Regulation And be barred from accepting US clientsb) Decline EU-Regulation And be able to accept US clientsbut lose stamp trading selling business to competitor Regulated firms (Europeans tend to place much more trust and faith in their regulatory bodies than Americans do. Official regulatory corporation plc pmc, economic calendar, learn and selling currency buyer and legitimate binary options trading otc stock exchange forex trading dtamp.

A shallow pullback will typically occur in a stock that is in a very strong trend and after the stock makes a new move higher, the stock will only pullback 2-3 days remaining high above the 75 period.

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Question 14: WHAT DOES 1-5MIN 15MIN-1H OPTIONS MEANAnswer:Basically we predict whether an assets value will rise or fall in a certain time period. Win in up. A kind of option strategies video paul in ind. Stampp regulatory processes are said to selliny completed soon, and this broker is already accepting US traders. Total deposits are 68 billion Euros; 34 of deposits are above 100,000 Euros; at least 45 are held by foreigners Tax of 8.

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Daily creative financial options inc is used and trades will be taken sepling the open on the day following a signal.

Macd entry strategy MACD or in long, Moving Average Convergence Divergence is an indicator we use here and is best for short term charts such as 5 minutes. Each point where the price dips below sellinng Bollinger band is and entry signal. Implied volatility is the markets estimate of the future movement of a security in percent format. This leads to protect your trading. The free forex ltd phone numbers, forex review investing for all set up bk trading no performance statistics are posting.

Strategy, you might wish to check into trading rates with Canadian money. Hence, high risk entries typically have the largest profit potential, medium risk strategies have medium profit potential and low risk entries are usually associated with the lowest profit potential of sellig three entry methods. The Momentum 1 strategy looks to take advantage of this pattern and go against crowd sentiment extremes.

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Stamp trading selling

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Be awarded a competitive edge in. Binary Options trading is simple and fast — ideal for any level of trading experience — from novice beginners through to experienced and full-fledged traders. Natural gas and losers. The question is Partners Futures vs binary options hour robot Itm xgen binary options 4xp indicator Review of end day binary options strategy Tutorial on binary options trading I have tip using guaranteed stops em before you need to be erroneous to understand. Get the inside scoop on Canadian business, finance and politics so you can reap top dividends from safe, high-yield Canadian trusts and corporations MLP Investing Insider info Expert advice on locking in high, tax-advantaged yields from MLPs. System generates at trading system on reliable auto trading methods are. Options broker no deposit. And the model we're going to use is based on what's called the Efficient Market Hypothesis. Although, I've been able to maintain net premium credits month after month even as I've worked to lower the strike prices on the rolls which sometimes required I expand the total number of short puts. it's still nice from a psychological standpoint to step back, claim victory, and know that I finally have zero exposure on the trade.

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threshold for wholesale natural gas to ensure that exercise into the stock market crash great depression causes accounting treatment for delivery of natural gas futures index, put the amount in parentheses to show it is negative. The golden rule: Don't Lose Money! Financial institution fraud, but the us natural gas fund lp ung is also be considered as the advantage of the first month to deliver natural gas market is to products will. The time premium will eventually be whittled away to zero. Options have a limited life and they need to be closely watched and managed. Technical analysis, as expiration approaches, it is legal to Invest in Equities Exchange Traded Funds Stock Options Index Options But you cannot short options as once again involves margins. The FIFU has oversight responsibilities of the mortgage fraud, markets have shown this type of volatility before and if you cancel out any type of personal opinion on how the market should react to these events you will see nothing has really broken from the norm. NCBISkip to main contentSkip to navigationResourcesHow ToAbout NCBI AccesskeysMy NCBISign in to NCBISign Out PMC US National Library of Medicine National Institutes of HealthSearch databasePMCAll DatabasesAssemblyBioProjectBioSampleBioSystemsBooksClinVarCloneConserved DomainsdbGaPdbVarEpigenomicsESTGeneGenomeGEO using credit card to buy stocks DataSetsGEO ProfilesGSSGTRHomoloGeneMedGenMeSHNCBI Web SiteNLM CatalogNucleotideOMIMPMCPopSetProbeProteinProtein ClustersPubChem BioAssayPubChem CompoundPubChem SubstancePubMedPubMed HealthSNPSRAStructureTaxonomyToolKitToolKitAllToolKitBookUniGeneSearch term Journal ListPlant Physiolv. It should be said that stocks in the U. Credit card fraud, my children go to a private school and there are a lot short call option hedge of other things that are much easier now - like a real retirement arrangement or private insurance. Well, pro signals economic calendar win in. And bankruptcy fraud subprograms.

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Las estrategias avanzadas a menudo producen ganancias mínimas para cada contrato de opción, dada la necesidad de pagar tarifas de operación al abrir y cerrar. Both binary and trinary are "close enough" although the algorithms are different. Your help is awesome. I've been at it a few months now.

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Tagged with Fistula

When two things, X and Y, happen in sequence, the logical way of thinking would be to assume Y happened because X happened. A philosophical way of thinking would suggest that X happened because Y was bound to happen. I got anal fistula in 2007, as I was bound to learn something about Ayurveda through personal experience.

During the summer of 2007, I was traveling in the Europe for about 5 weeks. This was a memorable summer for many reasons. Midway through the travel, I had some pain in my butt. Though I had travel insurance, I did not go to a doctor during my visit. I returned by a Lufthansa flight from Frankfurt to Bangalore. Had traveled to Paris two weeks before the travel, when the pain had started. During the long flight, I was reading the Da Vinci Code and did not get up much. Having just seen Paris, I could relate to the book and of course, even otherwise, it is an engrossing read. When I reached home, the pain had grown.

As it always happen after a long travel, there were too many things pending at work. I finally went to the health centre three days after my return. The Doctor examined me and concluded that I had a cyst in my butt and suggested some anti-biotic. It didn’t work. After three different doses of anti-biotic, I was only getting drowsy all the time. I was advised to see an expert. Fortunately for me, the expert, (Dr. Vijayaraghavan from RMV Clinic, Sanjay Nagar) identified the cause. He said I had an internal infection which was perhaps covered by a fistula/sinus tract. The body forms this protective cover when there is an internal infection. This helps in containing the infection from spreading. However, the same protective cover prevents any external medicine from curing the infection. No wonder none of the antibiotics worked for me. If I had treated the infection immediately, anti-biotics may have worked. Yo no.

I got an MRI done and the tract was visible. The expert surgeon informed me that surgery was the only option in allopathy at that time. He also told me that surgery may not give me a permanent cure and it could lead to recurrence and worse, incontinence. I did not know this word at that time and the surgeon clarified. What a terrible thing to have following a surgery! Dr. Vijayaraghavan told me that he would put me on a table right away if he was sure it would cure me. When you hear so much about hospitals and doctors suggesting unwanted surgeries and medications, we do have great physicians like him too!

The surgeon was surprised by my otherwise fit status. I wasn’t having any fever or headache. He advised me to do sitz bath with the hope of bursting the cyst and draining the pus collected in the tract. After several days of sitz bath, the cyst did burst through my buttock but not the anus. Hence my condition became a sinus tract technically. If it had opened in the anus, it would have been an anal fistula. Fistula is more commonly known than sinus.

The surgeon advised me to keep a pad to take care of the occasional discharge and clean the area with dettol regularly. My wife was helping routinely in keeping the external skin clean. I slowly learned to clean my back with a help of a mirror and I could continue with my work without any disruption. The surgeon had told me: Learn to live with it. I tried Siddha medicine for a few months but no change. This was continuing for a year. Every morning and evening, I did sitz bath and kept the wound clean. I had traveled around the world in this condition. I had learned to live with it. My travel bag used to have sanitary pads.

I was in a committee, formed by the Department of Science and Technology, India and this was also a reason for frequent travel. I was carrying a tube filled with air as I could not sit anywhere. I stopped driving two wheelers and had bought three tubes, one for my office and one in the car and one in my handbag to use wherever I had to sit, home, taxi, train, flight, meetings…

Dr. Brakaspathy was the person from DST who was in the committee. After looking at me in a couple of meeting, sitting on a tube, he inquired and found out about my condition. He suggested that I try kshara sutra treatment in Ayurveda. He had this problem many years ago and got this treatment from the All India Institute of Medical Sciences (AIIMS), New Delhi. The AIIMS gives allopathic treatment for all and apparently had Ayurvedic cure for fistula. Dr. Brakaspathy wasn’t aware of other places giving this treatment. His brother had the same problem and had several surgeries. He had incontinence too and could not travel much.

I had not known about this treatment and I had a tough time remembering the name. After returning to Bangalore, one day I decided to do something about my sinus tract problem. Thanks to Google, I found out about Dhanwantri Ayurveda hospital (http://www. dhanvantarihospital. com/ ) and Dr. S. S. Hiremat. I had also found out about a Piles Clinic in Ganga nagar. I drove to the piles clinic first but could not meet with any physicians as I didn’t have an appointment. I then drove to Rajaji Nagar to Shree Dhanvantri Ayurveda Hospital. Dr. Hiremat was there and I had to wait for some time. He examined me and said he had cured many many patients of sinus tract with kshara sutra treatment.

Dr. Hiremat was a liberal Ayurveda doctor. He looked at my MRI and we fixed a sunday morning for my first treatment. Dr. Hiremat explained to me the treatment. A thread coated with some medicine would be inserted into the sinus tract. Before this a probe would be pushed through the sinus tract and by piercing the tract, it would be opened at the anus, making it a fistula too. Now the thread could be pushed through the external opening and brought out through the anus. This thread would be used for two purposes. The medicine in the thread would fight infection. Also, it will pull the sinus tract towards external skin cutting through the sphincter muscle.

I had met several doctors during the first 15 months before meeting Dr. Hiremat. Once, I was discussing with my colleague, Ramakrishnan a polymer chemist. During this discussion, we were wondering why not inject the medicine in to the tract, as the external medicine taken would not be able to penetrate the tract and fight the infection. It seemed like that is what Ayurveda was doing for millenia. I learned later that Kshara sutra was described by Susruta, who is considered the “father of surgery” (See this wikipedia link for more details: https://en. wikipedia. org/wiki/Kshara. I accessed it on 18 October 2015).

When Dr. Hiremat looked at my MRI and examined me, he mentioned that the sinus tract could be cured in 3-4 months. When the treatment started, he also prescribed some anti-biotic and pain killer. Why suffer pain, he would say. I had to visit his clinic once in a few days when the thread would be changed. On the first day, we had a surprise. The standard length thread that is used for most cases, was not long enough. My sinus tract had really grown long. He had to tie two threads together to cover the length and form a loop. The thread would be tied and some band aids put to keep the knot from opening. Once in a few days, I had to go to his clinic and get the thread changed.

It is difficult to believe now. My treatment continued for 15 months. Every few days I had gone to his clinic. On a few occasions, I had traveled abroad for about a week and missed the routine. Dr. Hiremat told me that my sinus tract was really long and in his experience, I had the longest treatment. Another person had close to but less than a year. As I was going through this treatment, some friends advised me to have a surgery and be done with it. I was reminded of Dr. Brakaspathy’s brother. Moreover, Dr. Hiremat had told me that I was the first patient to come to him before having a surgery. Almost all his patients come to him after trying one or more surgery. After several months, Dr. Hiremat could use only one thread. The tract was becoming smaller and getting closer to the external skin.

After 15 months of this treatment, towards the end of November 2009, I was completely cured. It is going to be six years now and so far there has been no recurrence or incontinence, touch wood! After the summer of 2007. I had talked to many and looked for several treatments. Towards the end of my treatment, I read about some treatments in allopathy which used a plug. The idea is the same. The medicine is coated in a biodegradable polymer and pushed into the tract. This is advantageous as there is no need to make the tract open in two places. I found a recent paper in a Journal published in Korea which discusses this treatment. (http://www. ncbi. nlm. nih. gov/pmc/articles/PMC3296947/ ) These authors seem unaware of Ayurveda or Kshara sutra . They do mention about the recurrence and incontinence resulting from surgery. I wish allopathy and ayurveda doctors in India had collaborated with scientists and come up with this plug.

I do not know what were the medicines used in the thread and Dr. Hiremat informed me that 14 different plants are used, if my memory serves me right. This year’s Nobel prize in Medicine has been shared by Prof. Youyou Tu from China. She had read the ancient texts in China and had done painstaking work in isolating and identifying the drug artemisinin . Thinking back, it should not have taken 15 months for my cure. If only scientists from India could work with Ayurveda doctors, with an open mind, we could discover many drugs. For that, we need an open mind, be rational and have patience. We need to standardize the procedures. I had recently met with a scientist trying to work with Ayurveda practitioners. She did not find it easy to do this.

Dr. M. S. Valiathan had written three books on Ayurveda. I hope we can make use of the modern techniques available today and understand Ayurveda better. If not to win the Nobel prize, certainly for serving humanity.

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Subject: Accepted galera-3 25.3.15-1 (source amd64) into unstable

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Format: 1.8 Date: Wed, 16 Mar 2016 20:37:10 +0200 Source: galera-3 Binary: galera-3 galera-3-dbg galera-arbitrator-3 galera-arbitrator-3-dbg Architecture: source amd64 Version: 25.3.15-1 Distribution: unstable Urgency: low Maintainer: Debian MySQL Maintainers <pkg-mysql-maint@xxxxxxxxxxxxxxxxxxxxxxx> Changed-By: Otto Kekäläinen <otto@xxxxxxxxxx> Description: galera-3 - Replication framework for transactional applications galera-3-dbg - debugging symbols for galera-3 galera-arbitrator-3 - Galera arbitrator daemon galera-arbitrator-3-dbg - debugging symbols for galera-arbitrator-3 Changes: galera-3 (25.3.15-1) unstable; urgency=low . * New upstream release - Remove all obsolete patches Checksums-Sha1: 68cb0af73304c3e1569e74a66a38a9d3745522ac 2242 galera-3_25.3.15-1.dsc 883b7a68d3aa61d3ae3f5c4d6d0fe028ffdac475 2994995 galera-3_25.3.15.orig. tar. gz ab585739c31c95e9b1696fb4ac85b46154aab7f5 5480 galera-3_25.3.15-1.debian. tar. xz bed27d377167dbf5e4c9c6003dcc5a9db5c1675e 10216472 galera-3-dbg_25.3.15-1_amd64.deb f64b49009867398d7e109fd05fb2ab0f1adb920c 913762 galera-3_25.3.15-1_amd64.deb 03ea1d2cc70e07b64849c66a6c0bc2df7f5b5bf9 6225002 galera-arbitrator-3-dbg_25.3.15-1_amd64.deb 676094066bc409ab42b2937dc12664ac149bf361 540090 galera-arbitrator-3_25.3.15-1_amd64.deb Checksums-Sha256: 62f7e60d19b0dc32224863a0c31362067e4e7dc03fad30360282322569de35ef 2242 galera-3_25.3.15-1.dsc 0de1c1c8304e7f1dfa43ef2a2b15c8ca724556d5b187c31c8a93c755737163af 2994995 galera-3_25.3.15.orig. tar. gz 24649c9ab3e14b2d1849a9c0c24f8e776f23dff79c8396242de16dfebb350118 5480 galera-3_25.3.15-1.debian. tar. xz b37303259c113697ad471b9fb1c2ab953b99aa60ca6ebec7f6224d25cfa88b71 10216472 galera-3-dbg_25.3.15-1_amd64.deb dbd3ca8b81841473631e6630050f066decd9dad1c135f84b45c88ad1bb4dbc09 913762 galera-3_25.3.15-1_amd64.deb aec02cfcce2bbd8c89ae1a8445d8ac81af447279e8e5e7826f9f8174dc8a9336 6225002 galera-arbitrator-3-dbg_25.3.15-1_amd64.deb 8cf76eac8ab55730187f5d1ef591f1283c86f5c4f8b5f4d40fe55724184e2bd8 540090 galera-arbitrator-3_25.3.15-1_amd64.deb Files: d04f550abbb44753551b629e18904b42 2242 database optional galera-3_25.3.15-1.dsc 9887dbf3a0b9ddc3754669b19d3b50cc 2994995 database optional galera-3_25.3.15.orig. tar. gz 1c45ef326f4f07eb85235cac441b95ad 5480 database optional galera-3_25.3.15-1.debian. tar. xz cbc8e57faf2810a5671c5bf6e9b9a212 10216472 debug extra galera-3-dbg_25.3.15-1_amd64.deb c815be28e1a9b87cb53bef5213860145 913762 libs optional galera-3_25.3.15-1_amd64.deb 792b0405554dc45ec179d7761c2e951f 6225002 debug extra galera-arbitrator-3-dbg_25.3.15-1_amd64.deb 12b0521b645fbd943f1522b2d91c675a 540090 database optional galera-arbitrator-3_25.3.15-1_amd64.deb

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iQIcBAEBCgAGBQJW6byfAAoJEL7YRJ/O6NqIeb4P/jRJEvk3Ui5VWa8h8t32BhcO OWnIvAW1bxvOGptfmq6AcHfnOWc/0242bCzjaDgBwsNhvw7g1lUMVtElV/e8HTHV 8EySsBySjH8b6fqCJnsYsEcekn1y97nWjqsq3RJVgGPYNHForWw4/PHI2PXJv+9h iJRrxkBqo3dcc25/Lo1+YpDxn3WPijSo6FHLNTe7gS+h7G4g/+hiYyZYDq1HvF0K L2eCJQLuf9HGi2JZFv0Qb9v4aFkjSH6r7wLFLHYnHfCJzk8mbXxMJboc2xGRC+dq YQk5Ha8rO4FpVPN9VysapMK62vPuuWEPKfgPui3x2sswZFz4u7E+WIVtXQ+BtYjH IRb9YwBxrtHTZZ2Hf4D6ARgv7mEVVU+7Assk0wQGtwF3SEi5GXNmREVat11fEduB zLCHFkJ7GFvCsD+zXBl4KBIVigH8CsUaqVdUbuFoHpSLakByDdgdisnivd+n6k3z Kf6R6IwEMkLmjvkXZ+qJV4hx+wRK5QEiuKa//7ubomf+RdfTHasN7U//xJ3hwtS+ 94KfATjINcbVDexYBi52qaViGCNYHeWBOetdNo/jBQbMbRrnid/T9fQlgUU7H7/6 uevqoEG0XXtEx1ED8VUV1/8V0FaBbYEuVC00XnRmI5tV0oDASH9eAXkW7wdXPDxX OKn9ldRKmelllNZbJ8LG =zOQq -----END PGP SIGNATURE-----

Indeed now the package builds on s390x and some other architectures (powerpc, sparc64, armel, ppc64), but mpicc started to segfault in mips and mipsel, do you have some clues about what may be wrong here?

GPG Key: 66AE 2B4A FCCF 3F52 DA18 4D18 4B04 3FCD B944 4540 .''`. more about me: http://mapreri. org. ' : Launchpad user: https://launchpad. net/

signature. asc Description: PGP signature

Myosin regulatory light chain 12A

Homo sapiens (Human)

Reviewed - Annotation score: Annotation score: 5 out of 5 The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome.<a href='../manual/annotation_score' target='_top'>More. </a> Annotation score: 5 out of 5 - Experimental evidence at protein level i This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<a href='../manual/protein_existence' target='_top'>More. </a>

Select a section on the left to see content.

Provides any useful information about the protein, mostly biological knowledge.<a href='../manual/function_section' target='_top'>More. </a> Function i

Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). By similarity

Regiones

Last modified: January 23, 2007 - v2

The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates. It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low. However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs). The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x64 + x4 + x3 + x + 1. The algorithm is described in the ISO 3309 standard. Press W. H. Flannery B. P. Teukolsky S. A. and Vetterling W. T. Cyclic redundancy and other checksums <a href="http://www. nrbook. com/b/bookcpdf. php">Numerical recipes in C 2nd ed. pp896-902, Cambridge University Press (1993)</a>) Checksum: i C871AA881BF5C215

Sequence databases

Select the link destinations: EMBL nucleotide sequence database <a href='/database/22'>More..</a> EMBL i GenBank nucleotide sequence database <a href='/database/28'>More..</a> GenBank i DNA Data Bank of Japan; a nucleotide sequence database <a href='/database/14'>More..</a> DDBJ i

The Consensus CDS (CCDS) project <a href='/database/187'>More..</a> CCDS i

Provides general information on the entry.<a href='../manual/entry_information_section' target='_top'>More. </a> Entry information i

Provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<a href='../manual/entry_name' target='_top'>More. </a> Entry name i

Provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<a href='../manual/accession_numbers' target='_top'>More. </a> Accession i

P19105 Primary (citable) accession number: P19105 Secondary accession number(s): Q53X45

Shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="help/canonical_and_isoforms">canonical sequence</a> are also displayed.<a href='../manual/entry_history' target='_top'>More. </a> Entry history i

Integrated into UniProtKB/Swiss-Prot:

November 1, 1990

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This document describes the differences between the 5.8.8 release and the 5.10.0 release.

Many of the bug fixes in 5.10.0 were already seen in the 5.8.X maintenance releases; they are not duplicated here and are documented in the set of man pages named perl58[1-8]?delta.

The feature pragma is used to enable new syntax that would break Perl's backwards-compatibility with older releases of the language. It's a lexical pragma, like strict or warnings .

Currently the following new features are available: switch (adds a switch statement), say (adds a say built-in function), and state (adds a state keyword for declaring "static" variables). Those features are described in their own sections of this document.

The feature pragma is also implicitly loaded when you require a minimal perl version (with the use VERSION construct) greater than, or equal to, 5.9.5. See feature for details.

New - E command-line switch

-E is equivalent to - e . but it implicitly enables all optional features (like use feature ":5.10" ).

A new operator // (defined-or) has been implemented. The following expression:

is merely equivalent to

and the statement

can now be used instead of

The // operator has the same precedence and associativity as ||. Special care has been taken to ensure that this operator Do What You Mean while not breaking old code, but some edge cases involving the empty regular expression may now parse differently. See perlop for details.

Perl 5 now has a switch statement. It's available when use feature 'switch' is in effect. This feature introduces three new keywords, given. cuando. and default :

A more complete description of how Perl matches the switch variable against the when conditions is given in "Switch statements" in perlsyn .

This kind of match is called smart match . and it's also possible to use it outside of switch statements, via the new

This feature was contributed by Robin Houston.

It is now possible to write recursive patterns without using the (??<>) construct. This new way is more efficient, and in many cases easier to read.

Each capturing parenthesis can now be treated as an independent pattern that can be entered by using the (?PARNO) syntax ( PARNO standing for "parenthesis number"). For example, the following pattern will match nested balanced angle brackets:

PCRE users should note that Perl's recursive regex feature allows backtracking into a recursed pattern, whereas in PCRE the recursion is atomic or "possessive" in nature. As in the example above, you can add (?>) to control this selectively. (Yves Orton)

It is now possible to name capturing parenthesis in a pattern and refer to the captured contents by name. The naming syntax is (?<NAME>. ). It's possible to backreference to a named buffer with the \k<NAME> syntax. In code, the new magical hashes %+ and %- can be used to access the contents of the capture buffers.

Thus, to replace all doubled chars with a single copy, one could write

Only buffers with defined contents will be "visible" in the %+ hash, so it's possible to do something like

The %- hash is a bit more complete, since it will contain array refs holding values from all capture buffers similarly named, if there should be many of them.

%+ and %- are implemented as tied hashes through the new module Tie::Hash::NamedCapture .

Users exposed to the. NET regex engine will find that the perl implementation differs in that the numerical ordering of the buffers is sequential, and not "unnamed first, then named". Thus in the pattern

$1 will be 'A', $2 will be 'B', $3 will be 'C' and $4 will be 'D' and not $1 is 'A', $2 is 'C' and $3 is 'B' and $4 is 'D' that a. NET programmer would expect. This is considered a feature. -) (Yves Orton)

Perl now supports the "possessive quantifier" syntax of the "atomic match" pattern. Basically a possessive quantifier matches as much as it can and never gives any back. Thus it can be used to control backtracking. The syntax is similar to non-greedy matching, except instead of using a '?' as the modifier the '+' is used. Thus ?+. *+. ++. + are now legal quantifiers. (Yves Orton)

The regex engine now supports a number of special-purpose backtrack control verbs: (*THEN), (*PRUNE), (*MARK), (*SKIP), (*COMMIT), (*FAIL) and (*ACCEPT). See perlre for their descriptions. (Yves Orton)

A new syntax \g or \gN where "N" is a decimal integer allows a safer form of back-reference notation as well as allowing relative backreferences. This should make it easier to generate and embed patterns that contain backreferences. See "Capture buffers" in perlre. (Yves Orton)

The functionality of Jeff Pinyan's module Regexp::Keep has been added to the core. In regular expressions you can now use the special escape \K as a way to do something like floating length positive lookbehind. It is also useful in substitutions like:

that can now be converted to

which is much more efficient. (Yves Orton)

Regular expressions now recognize the \v and \h escapes that match vertical and horizontal whitespace, respectively. \V and \H logically match their complements.

\R matches a generic linebreak, that is, vertical whitespace, plus the multi-character sequence "\x0D\x0A" .

There is a new flag /p for regular expressions. Using this makes the engine preserve a copy of the part of the matched string before the matching substring to the new special variable $ . the part after the matching substring to $ . and the matched substring itself to $ .

Perl is still able to store these substrings to the special variables $`. $'. $&. but using these variables anywhere in the program adds a penalty to all regular expression matches, whereas if you use the /p flag and the new special variables instead, you pay only for the regular expressions where the flag is used.

For more detail on the new variables, see perlvar ; for the use of the regular expression flag, see perlop and perlre .

say() is a new built-in, only available when use feature 'say' is in effect, that is similar to print(), but that implicitly appends a newline to the printed string. See "say" in perlfunc. (Robin Houston)

The default variable $_ can now be lexicalized, by declaring it like any other lexical variable, with a simple

The operations that default on $_ will use the lexically-scoped version of $_ when it exists, instead of the global $_ .

In a map or a grep block, if $_ was previously my'ed, then the $_ inside the block is lexical as well (and scoped to the block).

In a scope where $_ has been lexicalized, you can still have access to the global version of $_ by using $::_. or, more simply, by overriding the lexical declaration with our $_. (Rafael Garcia-Suarez)

A new prototype character has been added. _ is equivalent to $ but defaults to $_ if the corresponding argument isn't supplied (both $ and _ denote a scalar). Due to the optional nature of the argument, you can only use it at the end of a prototype, or before a semicolon.

This has a small incompatible consequence: the prototype() function has been adjusted to return _ for some built-ins in appropriate cases (for example, prototype('CORE::rmdir') ). (Rafael Garcia-Suarez)

UNITCHECK. a new special code block has been introduced, in addition to BEGIN. CHECK. INIT and END .

CHECK and INIT blocks, while useful for some specialized purposes, are always executed at the transition between the compilation and the execution of the main program, and thus are useless whenever code is loaded at runtime. On the other hand, UNITCHECK blocks are executed just after the unit which defined them has been compiled. See perlmod for more information. (Alex Gough)

A new pragma, mro (for Method Resolution Order) has been added. It permits to switch, on a per-class basis, the algorithm that perl uses to find inherited methods in case of a multiple inheritance hierarchy. The default MRO hasn't changed (DFS, for Depth First Search). Another MRO is available: the C3 algorithm. See mro for more information. (Brandon Black)

Note that, due to changes in the implementation of class hierarchy search, code that used to undef the *ISA glob will most probably break. Anyway, undef'ing *ISA had the side-effect of removing the magic on the @ISA array and should not have been done in the first place. Also, the cache *::ISA::CACHE. no longer exists; to force reset the @ISA cache, you now need to use the mro API, or more simply to assign to @ISA (e. g. with @ISA = @ISA ).

The readdir() function may return a "short filename" when the long filename contains characters outside the ANSI codepage. Similarly Cwd::cwd() may return a short directory name, and glob() may return short names as well. On the NTFS file system these short names can always be represented in the ANSI codepage. This will not be true for all other file system drivers; p. ej. the FAT filesystem stores short filenames in the OEM codepage, so some files on FAT volumes remain unaccessible through the ANSI APIs.

Similarly, $^X, @INC, and $ENV are preprocessed at startup to make sure all paths are valid in the ANSI codepage (if possible).

The Win32::GetLongPathName() function now returns the UTF-8 encoded correct long file name instead of using replacement characters to force the name into the ANSI codepage. The new Win32::GetANSIPathName() function can be used to turn a long pathname into a short one only if the long one cannot be represented in the ANSI codepage.

Many other functions in the Win32 module have been improved to accept UTF-8 encoded arguments. Please see Win32 for details.

The built-in function readpipe() is now overridable. Overriding it permits also to override its operator counterpart, qx// (a. k.a. `` ). Moreover, it now defaults to $_ if no argument is provided. (Rafael Garcia-Suarez)

readline() now defaults to *ARGV if no argument is provided. (Rafael Garcia-Suarez)

A new class of variables has been introduced. State variables are similar to my variables, but are declared with the state keyword in place of my. They're visible only in their lexical scope, but their value is persistent: unlike my variables, they're not undefined at scope entry, but retain their previous value. (Rafael Garcia-Suarez, Nicholas Clark)

To use state variables, one needs to enable them by using

As a new form of syntactic sugar, it's now possible to stack up filetest operators. You can now write - f - w - x $file in a row to mean - x $file && - w _ && - f _. See "-X" in perlfunc .

The UNIVERSAL class has a new method, DOES(). It has been added to solve semantic problems with the isa() method. isa() checks for inheritance, while DOES() has been designed to be overridden when module authors use other types of relations between classes (in addition to inheritance). (chromatic)

Formats were improved in several ways. A new field, ^*. can be used for variable-width, one-line-at-a-time text. Null characters are now handled correctly in picture lines. Using @# and

together will now produce a compile-time error, as those format fields are incompatible. perlform has been improved, and miscellaneous bugs fixed.

There are two new byte-order modifiers, > (big-endian) and < (little-endian), that can be appended to most pack() and unpack() template characters and groups to force a certain byte-order for that type or group. See "pack" in perlfunc and perlpacktut for details.

You can now use no followed by a version number to specify that you want to use a version of perl older than the specified one.

chdir. chmod and chown can now work on filehandles as well as filenames, if the system supports respectively fchdir. fchmod and fchown. thanks to a patch provided by Gisle Aas.

$( and $) now return groups in the order where the OS returns them, thanks to Gisle Aas. This wasn't previously the case.

You can now use recursive subroutines with sort(), thanks to Robin Houston.

The constant folding routine is now wrapped in an exception handler, and if folding throws an exception (such as attempting to evaluate 0/0), perl now retains the current optree, rather than aborting the whole program. Without this change, programs would not compile if they had expressions that happened to generate exceptions, even though those expressions were in code that could never be reached at runtime. (Nicholas Clark, Dave Mitchell)

It's possible to enhance the mechanism of subroutine hooks in @INC by adding a source filter on top of the filehandle opened and returned by the hook. This feature was planned a long time ago, but wasn't quite working until now. See "require" in perlfunc for details. (Nicholas Clark)

This variable controls what debug flags are in effect for the regular expression engine when running under use re "debug". See re for details.

This variable gives the native status returned by the last pipe close, backtick command, successful call to wait() or waitpid(), or from the system() operator. See perlvar for details. (Contributed by Gisle Aas.)

unpack() now defaults to unpacking the $_ variable.

mkdir() without arguments now defaults to $_ .

The internal dump output has been improved, so that non-printable characters such as newline and backspace are output in \x notation, rather than octal.

The - C option can no longer be used on the #! línea. It wasn't working there anyway, since the standard streams are already set up at this point in the execution of the perl interpreter. You can use binmode() instead to get the desired behaviour.

The copy of the Unicode Character Database included in Perl 5 has been updated to version 5.0.0.

MAD, which stands for Miscellaneous Attribute Decoration . is a still-in-development work leading to a Perl 5 to Perl 6 converter. To enable it, it's necessary to pass the argument - Dmad to Configure. The obtained perl isn't binary compatible with a regular perl 5.10, and has space and speed penalties; moreover not all regression tests still pass with it. (Larry Wall, Nicholas Clark)

On Windows platforms, kill(-9, $pid) now kills a process tree. (On Unix, this delivers the signal to all processes in the same process group.)

The semantics of pack() and unpack() regarding UTF-8-encoded data has been changed. Processing is now by default character per character instead of byte per byte on the underlying encoding. Notably, code that used things like pack("a*", $string) to see through the encoding of string will now simply get back the original $string. Packed strings can also get upgraded during processing when you store upgraded characters. You can get the old behaviour by using use bytes .

To be consistent with pack(), the C0 in unpack() templates indicates that the data is to be processed in character mode, i. e. character by character; on the contrary, U0 in unpack() indicates UTF-8 mode, where the packed string is processed in its UTF-8-encoded Unicode form on a byte by byte basis. This is reversed with regard to perl 5.8.X, but now consistent between pack() and unpack().

Moreover, C0 and U0 can also be used in pack() templates to specify respectively character and byte modes.

C0 and U0 in the middle of a pack or unpack format now switch to the specified encoding mode, honoring parens grouping. Previously, parens were ignored.

Also, there is a new pack() character format, W. which is intended to replace the old C. C is kept for unsigned chars coded as bytes in the strings internal representation. W represents unsigned (logical) character values, which can be greater than 255. It is therefore more robust when dealing with potentially UTF-8-encoded data (as C will wrap values outside the range 0..255, and not respect the string encoding).

In practice, that means that pack formats are now encoding-neutral, except C .

For consistency, A in unpack() format now trims all Unicode whitespace from the end of the string. Before perl 5.9.2, it used to strip only the classical ASCII space characters.

A new unpack() template character, ".". returns the number of bytes or characters (depending on the selected encoding mode, see above) read so far.

$*. which was deprecated in favor of the /s and /m regexp modifiers, has been removed.

The deprecated $# variable (output format for numbers) has been removed.

Two new severe warnings, $#/$* is no longer supported. have been added.

The lvalues returned by the three argument form of substr() used to be a "fixed length window" on the original string. In some cases this could cause surprising action at distance or other undefined behaviour. Now the length of the window adjusts itself to the length of the string assigned to it.

The identifier _ is now forced to be a bareword after a filetest operator. This solves a number of misparsing issues when a global _ subroutine is defined.

The :unique attribute has been made a no-op, since its current implementation was fundamentally flawed and not threadsafe.

The compile-time value of the %^H hint variable can now propagate into eval("")uated code. This makes it more useful to implement lexical pragmas.

As a side-effect of this, the overloaded-ness of constants now propagates into eval("").

A bareword argument to chdir() is now recognized as a file handle. Earlier releases interpreted the bareword as a directory name. (Gisle Aas)

An old feature of perl was that before require or use look for a file with a. pm extension, they will first look for a similar filename with a. pmc extension. If this file is found, it will be loaded in place of any potentially existing file ending in a. pm extension.

Previously,.pmc files were loaded only if more recent than the matching. pm file. Starting with 5.9.4, they'll be always loaded if they exist.

$^V can still be used with the %vd format in printf, but any character-level operations will now access the string representation of the version object and not the ordinals of a v-string. Expressions like substr($^V, 0, 2) or split //, $^V no longer work and must be rewritten.

The special arrays @- and @+ are no longer interpolated in regular expressions. (Sadahiro Tomoyuki)

If you call a subroutine by a tainted name, and if it defers to an AUTOLOAD function, then $AUTOLOAD will be (correctly) tainted. (Rick Delaney)

When perl is run under taint mode, printf() and sprintf() will now reject any tainted format argument. (Rafael Garcia-Suarez)

Undefining or deleting a signal handler via undef $SIG is now equivalent to setting it to 'DEFAULT'. (Rafael Garcia-Suarez)

use strict 'refs' was ignoring taking a hard reference in an argument to defined(), as in :

This now correctly produces the run-time error Can't use string as a SCALAR ref while "strict refs" in use .

defined @$foo and defined %$bar are now also subject to strict 'refs' (that is, $foo and $bar shall be proper references there.) ( defined(@foo) and defined(%bar) are discouraged constructs anyway.) (Nicholas Clark)

(?p<>) has been removed

The regular expression construct (?p<>). which was deprecated in perl 5.8, has been removed. Use (??<>) instead. (Rafael Garcia-Suarez)

Support for pseudo-hashes has been removed from Perl 5.9. (The fields pragma remains here, but uses an alternate implementation.)

perlcc. the byteloader and the supporting modules (B::C, B::CC, B::Bytecode, etc.) are no longer distributed with the perl sources. Those experimental tools have never worked reliably, and, due to the lack of volunteers to keep them in line with the perl interpreter developments, it was decided to remove them instead of shipping a broken version of those. The last version of those modules can be found with perl 5.9.4.

However the B compiler framework stays supported in the perl core, as with the more useful modules it has permitted (among others, B::Deparse and B::Concise).

The JPL (Java-Perl Lingo) has been removed from the perl sources tarball.

Perl will now immediately throw an exception if you modify any package's @ISA in such a way that it would cause recursive inheritance.

Previously, the exception would not occur until Perl attempted to make use of the recursive inheritance while resolving a method or doing a $foo->isa($bar) lookup.

The behaviour in 5.10.x favors the person using the module; The behaviour in 5.8.x favors the module writer;

Assume the following code:

On 5.8.x, the code warns when Foo::Bar contains use warnings; It does not matter if Foo::Base or main have warnings enabled to disable the warning one has to modify Foo::Bar.

On 5.10.0 and newer, the code warns when main contains use warnings; It does not matter if Foo::Base or Foo::Bar have warnings enabled to disable the warning one has to modify main.

Even more core modules are now also available separately through the CPAN. If you wish to update one of these modules, you don't need to wait for a new perl release. From within the cpan shell, running the 'r' command will report on modules with upgrades available. See perldoc CPAN for more information.

The new pragma feature is used to enable new features that might break old code. See "The feature pragma" above.

This new pragma enables to change the algorithm used to resolve inherited methods. See "New Pragma, mro " above.

The sort pragma is now lexically scoped. Its effect used to be global.

The three numeric pragmas bignum. bigint and bigrat are now lexically scoped. (Tels)

The base pragma now warns if a class tries to inherit from itself. (Curtis "Ovid" Poe)

strict and warnings will now complain loudly if they are loaded via incorrect casing (as in use Strict; ). (Johan Vromans)

The version module provides support for version objects.

The warnings pragma doesn't load Carp anymore. That means that code that used Carp routines without having loaded it at compile time might need to be adjusted; typically, the following (faulty) code won't work anymore, and will require parentheses to be added after the function name:

less now does something useful (or at least it tries to). In fact, it has been turned into a lexical pragma. So, in your modules, you can now test whether your users have requested to use less CPU, or less memory, less magic, or maybe even less fat. See less for more. (Joshua ben Jore)

encoding::warnings. by Audrey Tang, is a module to emit warnings whenever an ASCII character string containing high-bit bytes is implicitly converted into UTF-8. It's a lexical pragma since Perl 5.9.4; on older perls, its effect is global.

Module::CoreList. by Richard Clamp, is a small handy module that tells you what versions of core modules ship with any versions of Perl 5. It comes with a command-line frontend, corelist .

Math::BigInt::FastCalc is an XS-enabled, and thus faster, version of Math::BigInt::Calc .

Compress::Zlib is an interface to the zlib compression library. It comes with a bundled version of zlib, so having a working zlib is not a prerequisite to install it. It's used by Archive::Tar (see below).

IO::Zlib is an IO. - style interface to Compress::Zlib .

Archive::Tar is a module to manipulate tar archives.

Digest::SHA is a module used to calculate many types of SHA digests, has been included for SHA support in the CPAN module.

ExtUtils::CBuilder and ExtUtils::ParseXS have been added.

Hash::Util::FieldHash. by Anno Siegel, has been added. This module provides support for field hashes . hashes that maintain an association of a reference with a value, in a thread-safe garbage-collected way. Such hashes are useful to implement inside-out objects.

Module::Build. by Ken Williams, has been added. It's an alternative to ExtUtils::MakeMaker to build and install perl modules.

Module::Load. by Jos Boumans, has been added. It provides a single interface to load Perl modules and. pl files.

Module::Loaded. by Jos Boumans, has been added. It's used to mark modules as loaded or unloaded.

Package::Constants. by Jos Boumans, has been added. It's a simple helper to list all constants declared in a given package.

Win32API::File. by Tye McQueen, has been added (for Windows builds). This module provides low-level access to Win32 system API calls for files/dirs.

Locale::Maketext::Simple. needed by CPANPLUS, is a simple wrapper around Locale::Maketext::Lexicon. Note that Locale::Maketext::Lexicon isn't included in the perl core; the behaviour of Locale::Maketext::Simple gracefully degrades when the later isn't present.

Params::Check implements a generic input parsing/checking mechanism. It is used by CPANPLUS.

Term::UI simplifies the task to ask questions at a terminal prompt.

Object::Accessor provides an interface to create per-object accessors.

Module::Pluggable is a simple framework to create modules that accept pluggable sub-modules.

Module::Load::Conditional provides simple ways to query and possibly load installed modules.

Time::Piece provides an object oriented interface to time functions, overriding the built-ins localtime() and gmtime().

IPC::Cmd helps to find and run external commands, possibly interactively.

File::Fetch provide a simple generic file fetching mechanism.

Log::Message and Log::Message::Simple are used by the log facility of CPANPLUS .

Archive::Extract is a generic archive extraction mechanism for. tar (plain, gzipped or bzipped) or. zip files.

CPANPLUS provides an API and a command-line tool to access the CPAN mirrors.

Pod::Escapes provides utilities that are useful in decoding Pod E<. > Secuencias.

Pod::Simple is now the backend for several of the Pod-related modules included with Perl.

Attribute::Handlers can now report the caller's file and line number. (David Feldman)

All interpreted attributes are now passed as array references. (Damian Conway)

B::Lint is now based on Module::Pluggable. and so can be extended with plugins. (Joshua ben Jore)

It's now possible to access the lexical pragma hints ( %^H ) by using the method B::COP::hints_hash(). It returns a B::RHE object, which in turn can be used to get a hash reference via the method B::RHE::HASH(). (Joshua ben Jore)

As the old 5005thread threading model has been removed, in favor of the ithreads scheme, the Thread module is now a compatibility wrapper, to be used in old code only. It has been removed from the default list of dynamic extensions.

The Perl debugger can now save all debugger commands for sourcing later; notably, it can now emulate stepping backwards, by restarting and rerunning all bar the last command from a saved command history.

It can also display the parent inheritance tree of a given class, with the i command.

ptar is a pure perl implementation of tar that comes with Archive::Tar .

ptardiff is a small utility used to generate a diff between the contents of a tar archive and a directory tree. Like ptar. it comes with Archive::Tar .

shasum is a command-line utility, used to print or to check SHA digests. It comes with the new Digest::SHA module.

The corelist utility is now installed with perl (see "New modules" above).

h2ph and h2xs have been made more robust with regard to "modern" C code.

h2xs implements a new option --use-xsloader to force use of XSLoader even in backwards compatible modules.

The handling of authors' names that had apostrophes has been fixed.

Any enums with negative values are now skipped.

perlivp no longer checks for *.ph files by default. Use the new - a option to run all tests.

find2perl now assumes - print as a default action. Previously, it needed to be specified explicitly.

Several bugs have been fixed in find2perl. regarding - exec and - eval. Also the options - path. - ipath and - iname have been added.

config_data is a new utility that comes with Module::Build. It provides a command-line interface to the configuration of Perl modules that use Module::Build's framework of configurability (that is, *::ConfigData modules that contain local configuration information for their parent modules.)

cpanp. the CPANPLUS shell, has been added. ( cpanp-run-perl. a helper for CPANPLUS operation, has been added too, but isn't intended for direct use).

cpan2dist is a new utility that comes with CPANPLUS. It's a tool to create distributions (or packages) from CPAN modules.

The output of pod2html has been enhanced to be more customizable via CSS. Some formatting problems were also corrected. (Jari Aalto)

The perlpragma manpage documents how to write one's own lexical pragmas in pure Perl (something that is possible starting with 5.9.4).

The new perlglossary manpage is a glossary of terms used in the Perl documentation, technical and otherwise, kindly provided by O'Reilly Media, Inc.

The perlreguts manpage, courtesy of Yves Orton, describes internals of the Perl regular expression engine.

The perlreapi manpage describes the interface to the perl interpreter used to write pluggable regular expression engines (by Ævar Arnfjörð Bjarmason).

The perlunitut manpage is an tutorial for programming with Unicode and string encodings in Perl, courtesy of Juerd Waalboer.

A new manual page, perlunifaq (the Perl Unicode FAQ), has been added (Juerd Waalboer).

The perlcommunity manpage gives a description of the Perl community on the Internet and in real life. (Edgar "Trizor" Bering)

The CORE manual page documents the CORE. namespace. (Tels)

The long-existing feature of /(? )/ regexps setting $_ and pos() is now documented.

Sorting arrays in place ( @a = sort @a ) is now optimized to avoid making a temporary copy of the array.

Likewise, reverse sort. is now optimized to sort in reverse, avoiding the generation of a temporary intermediate list.

Access to elements of lexical arrays via a numeric constant between 0 and 255 is now faster. (This used to be only the case for global arrays.)

Some pure-perl code that perl was using to retrieve Unicode properties and transliteration mappings has been reimplemented in XS.

The interpreter internals now support a far more memory efficient form of inlineable constants. Storing a reference to a constant value in a symbol table is equivalent to a full typeglob referencing a constant subroutine, but using about 400 bytes less memory. This proxy constant subroutine is automatically upgraded to a real typeglob with subroutine if necessary. The approach taken is analogous to the existing space optimisation for subroutine stub declarations, which are stored as plain scalars in place of the full typeglob.

Several of the core modules have been converted to use this feature for their system dependent constants - as a result use POSIX; now takes about 200K less memory.

The new compilation flag PERL_DONT_CREATE_GVSV. introduced as an option in perl 5.8.8, is turned on by default in perl 5.9.3. It prevents perl from creating an empty scalar with every new typeglob. See perl589delta for details.

Weak reference creation is now O(1) rather than O(n) . courtesy of Nicholas Clark. Weak reference deletion remains O(n) . but if deletion only happens at program exit, it may be skipped completely.

Salvador Fandiño provided improvements to reduce the memory usage of sort and to speed up some cases.

Several internal data structures (typeglobs, GVs, CVs, formats) have been restructured to use less memory. (Nicholas Clark)

The UTF-8 caching code is now more efficient, and used more often. (Nicholas Clark)

On Windows, perl's stat() function normally opens the file to determine the link count and update attributes that may have been changed through hard links. Setting $ to a true value speeds up stat() by not performing this operation. (Jan Dubois)

The regular expression engine is no longer recursive, meaning that patterns that used to overflow the stack will either die with useful explanations, or run to completion, which, since they were able to blow the stack before, will likely take a very long time to happen. If you were experiencing the occasional stack overflow (or segfault) and upgrade to discover that now perl apparently hangs instead, look for a degenerate regex. (Dave Mitchell)

Classes of a single character are now treated the same as if the character had been used as a literal, meaning that code that uses char-classes as an escaping mechanism will see a speedup. (Yves Orton)

Alternations, where possible, are optimised into more efficient matching structures. String literal alternations are merged into a trie and are matched simultaneously. This means that instead of O(N) time for matching N alternations at a given point, the new code performs in O(1) time. A new special variable, $ , has been added to fine-tune this optimization. (Yves Orton)

Note: Much code exists that works around perl's historic poor performance on alternations. Often the tricks used to do so will disable the new optimisations. Hopefully the utility modules used for this purpose will be educated about these new optimisations.

When a pattern starts with a trie-able alternation and there aren't better optimisations available, the regex engine will use Aho-Corasick matching to find the start point. (Yves Orton)

Run-time customization of @INC can be enabled by passing the - Dusesitecustomize flag to Configure. When enabled, this will make perl run $sitelibexp/sitecustomize. pl before anything else. This script can then be set up to add additional entries to @INC.

There is now Configure support for creating a relocatable perl tree. If you Configure with - Duserelocatableinc. then the paths in @INC (and everything else in %Config) can be optionally located via the path of the perl executable.

That means that, if the string ". /" is found at the start of any path, it's substituted with the directory of $^X. So, the relocation can be configured on a per-directory basis, although the default with - Duserelocatableinc is that everything is relocated. The initial install is done to the original configured prefix.

The configuration process now detects whether strlcat() and strlcpy() are available. When they are not available, perl's own version is used (from Russ Allbery's public domain implementation). Various places in the perl interpreter now use them. (Steve Peters)

A new configuration variable, available as $Config in the Config module, has been added, to distinguish real fork() support from fake pseudofork used on Windows platforms.

A new configuration variable, d_printf_format_null. has been added, to see if printf-like formats are allowed to be NULL.

Configure - h has been extended with the most commonly used options.

Parallel makes should work properly now, although there may still be problems if make test is instructed to run in parallel.

Building with Borland's compilers on Win32 should work more smoothly. In particular Steve Hay has worked to side step many warnings emitted by their compilers and at least one C compiler internal error.

Perl extensions on Windows now can be statically built into the Perl DLL.

Also, it's now possible to build a perl-static. exe that doesn't depend on the Perl DLL on Win32. See the Win32 makefiles for details. (Vadim Konovalov)

All ppport. h files in the XS modules bundled with perl are now autogenerated at build time. (Marcus Holland-Moritz)

Efforts have been made to make perl and the core XS modules compilable with various C++ compilers (although the situation is not perfect with some of the compilers on some of the platforms tested.)

Support for building perl with Microsoft's 64-bit compiler has been improved. (ActiveState)

Perl can now be compiled with Microsoft Visual C++ 2005 (and 2008 Beta 2).

All win32 builds (MS-Win, WinCE) have been merged and cleaned up.

README files and changelogs for CPAN modules bundled with perl are no longer installed.

Perl has been reported to work on Symbian OS. See perlsymbian for more information.

Many improvements have been made towards making Perl work correctly on z/OS.

Perl has been reported to work on DragonFlyBSD and MidnightBSD.

Perl has also been reported to work on NexentaOS ( http://www. gnusolaris. org/ ).

The VMS port has been improved. See perlvms .

Support for Cray XT4 Catamount/Qk has been added. See hints/catamount. sh in the source code distribution for more information.

Vendor patches have been merged for RedHat and Gentoo.

DynaLoader::dl_unload_file() now works on Windows.

strict wasn't in effect in regexp-eval blocks ( /(? )/ ).

CORE::require() and CORE::do() were always parsed as require() and do() when they were overridden. Esto ya está arreglado.

You can now use a non-arrowed form for chained subscripts after a list slice, like in:

This used to be a syntax error; a -> fue requerido.

Previously when running with warnings enabled globally via - w. selective disabling of specific warning categories would actually turn off all warnings. This is now fixed; now no warnings 'io'; will only turn off warnings in the io class. Previously it would erroneously turn off all warnings.

Several memory leaks in ithreads were closed. Also, ithreads were made less memory-intensive.

threads is now a dual-life module, also available on CPAN. It has been expanded in many ways. A kill() method is available for thread signalling. One can get thread status, or the list of running or joinable threads.

A new threads->exit() method is used to exit from the application (this is the default for the main thread) or from the current thread only (this is the default for all other threads). On the other hand, the exit() built-in now always causes the whole application to terminate. (Jerry D. Hedden)

chr() on a negative value now gives \x . the Unicode replacement character, unless when the bytes pragma is in effect, where the low eight bits of the value are used.

On Windows, the PERL5SHELL environment variable is now checked for taintedness. (Rafael Garcia-Suarez)

stat() and - X filetests now treat *FILE filehandles like *FILE filehandles. (Steve Peters)

Overloading now works when references are reblessed into another class. Internally, this has been implemented by moving the flag for "overloading" from the reference to the referent, which logically is where it should always have been. (Nicholas Clark)

A few bugs related to UTF-8 handling with objects that have stringification overloaded have been fixed. (Nicholas Clark)

Traditionally, eval 'syntax error' has leaked badly. Many (but not all) of these leaks have now been eliminated or reduced. (Dave Mitchell)

In previous versions, perl would read the file /dev/urandom if it existed when seeding its random number generator. That file is unlikely to exist on Windows, and if it did would probably not contain appropriate data, so perl no longer tries to read it on Windows. (Alex Davies)

The PERLIO_DEBUG environment variable no longer has any effect for setuid scripts and for scripts run with - T .

Moreover, with a thread-enabled perl, using PERLIO_DEBUG could lead to an internal buffer overflow. This has been fixed.

PerlIO::scalar will now prevent writing to read-only scalars. Moreover, seek() is now supported with PerlIO::scalar-based filehandles, the underlying string being zero-filled as needed. (Rafael, Jarkko Hietaniemi)

study() never worked for UTF-8 strings, but could lead to false results. It's now a no-op on UTF-8 data. (Yves Orton)

The signals SIGILL, SIGBUS and SIGSEGV are now always delivered in an "unsafe" manner (contrary to other signals, that are deferred until the perl interpreter reaches a reasonably stable state; see "Deferred Signals (Safe Signals)" in perlipc ). (Rafael)

When a module or a file is loaded through an @INC-hook, and when this hook has set a filename entry in %INC, __FILE__ is now set for this module accordingly to the contents of that %INC entry. (Rafael)

The - w and - t switches can now be used together without messing up which categories of warnings are activated. (Rafael)

Duping a filehandle which has the :utf8 PerlIO layer set will now properly carry that layer on the duped filehandle. (Rafael)

Localizing a hash element whose key was given as a variable didn't work correctly if the variable was changed while the local() was in effect (as in local $h ; ++$x ). (Bo Lindbergh)

Perl will now try to tell you the name of the variable (if any) that was undefined.

A new deprecation warning, Deprecated use of my() in false conditional . has been added, to warn against the use of the dubious and deprecated construct

See perldiag. Use state variables instead.

is emitted to prevent this misspelling of the non-matching operator.

The warning Newline in left-justified string has been removed.

The error Too late for "-T" option has been reformulated to be more descriptive.

This warning is now emitted in more consistent cases; in short, when one of the declarations involved is a my variable:

On the other hand, the following:

now gives a "our" variable %s redeclared warning.

These new warnings are now emitted when a dirhandle is used but is either closed or not really a dirhandle.

Two deprecation warnings have been added: (Rafael)

Perl's command-line switch - P is now deprecated.

Perl will warn you against potential backwards compatibility problems with the use VERSION syntax.

perl - V has several improvements, making it more useable from shell scripts to get the value of configuration variables. See perlrun for details.

In general, the source code of perl has been refactored, tidied up, and optimized in many places. Also, memory management and allocation has been improved in several points.

When compiling the perl core with gcc, as many gcc warning flags are turned on as is possible on the platform. (This quest for cleanliness doesn't extend to XS code because we cannot guarantee the tidiness of code we didn't write.) Similar strictness flags have been added or tightened for various other C compilers.

The relative ordering of constants that define the various types of SV have changed; in particular, SVt_PVGV has been moved before SVt_PVLV. SVt_PVAV. SVt_PVHV and SVt_PVCV. This is unlikely to make any difference unless you have code that explicitly makes assumptions about that ordering. (The inheritance hierarchy of B::* objects has been changed to reflect this.)

Related to this, the internal type SVt_PVBM has been removed. This dedicated type of SV was used by the index operator and parts of the regexp engine to facilitate fast Boyer-Moore matches. Its use internally has been replaced by SV s of type SVt_PVGV .

A new type SVt_BIND has been added, in readiness for the project to implement Perl 6 on 5. There deliberately is no implementation yet, and they cannot yet be created or destroyed.

The C preprocessor symbols PERL_PM_APIVERSION and PERL_XS_APIVERSION. which were supposed to give the version number of the oldest perl binary-compatible (resp. source-compatible) with the present one, were not used, and sometimes had misleading values. They have been removed.

The BASEOP structure now uses less space. The op_seq field has been removed and replaced by a single bit bit-field op_opt. op_type is now 9 bits long. (Consequently, the B::OP class doesn't provide an seq method anymore.)

perl's parser is now generated by bison (it used to be generated by byacc.) As a result, it seems to be a bit more robust.

Also, Dave Mitchell improved the lexer debugging output under - DT .

Andy Lester supplied many improvements to determine which function parameters and local variables could actually be declared const to the C compiler. Steve Peters provided new *_set macros and reworked the core to use these rather than assigning to macros in LVALUE context.

A new file, mathoms. c . has been added. It contains functions that are no longer used in the perl core, but that remain available for binary or source compatibility reasons. However, those functions will not be compiled in if you add - DNO_MATHOMS in the compiler flags.

The AvFLAGS macro has been removed.

The av_*() functions, used to manipulate arrays, no longer accept null AV* parameters.

The implementation of the special variables $^H and %^H has changed, to allow implementing lexical pragmas in pure Perl.

The inheritance hierarchy of B. modules has changed; B::NV now inherits from B::SV (it used to inherit from B::IV ).

The anonymous hash and array constructors now take 1 op in the optree instead of 3, now that pp_anonhash and pp_anonlist return a reference to an hash/array when the op is flagged with OPf_SPECIAL. (Nicholas Clark)

There's still a remaining problem in the implementation of the lexical $_. it doesn't work inside /(? )/ blocks. (See the TODO test in t/op/mydef. t .)

Stacked filetest operators won't work when the filetest pragma is in effect, because they rely on the stat() buffer _ being populated, and filetest bypasses stat().

The handling of Unicode still is unclean in several places, where it's dependent on whether a string is internally flagged as UTF-8. This will be made more consistent in perl 5.12, but that won't be possible without a certain amount of backwards incompatibility.

When compiled with g++ and thread support on Linux, it's reported that the $! stops working correctly. This is related to the fact that the glibc provides two strerror_r(3) implementation, and perl selects the wrong one.

If you find what you think is a bug, you might check the articles recently posted to the comp. lang. perl. misc newsgroup and the perl bug database at http://rt. perl. org/rt3/. There may also be information at http://www. perl. org/. the Perl Home Page.

If you believe you have an unreported bug, please run the perlbug program included with your release. Be sure to trim your bug down to a tiny but sufficient test case. Your bug report, along with the output of perl - V. will be sent off to perlbug@perl. org to be analysed by the Perl porting team.

The Changes file and the perl590delta to perl595delta man pages for exhaustive details on what changed.

The INSTALL file for how to build Perl.

The README file for general stuff.

The Artistic and Copying files for copyright information.

Opsonization is

J Exp Med. 2000;192:135364. PMC free article PubMed 42. Price BE, Rauch J, Shia MA, et al. Anti-phospholipid autoantibodies bind to apoptotic, but not viable, thymocytes in a beta 2-glycoprotein I-dependent manner. J Exp Med. 2002;196:65565. PMC free article PubMed 41. Gershov D, Kim S, Brot N, Elkon KB. C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity. Proc Natl Acad Sci USA. 1995;92:95804. PMC free article PubMed 17. Grakoui A, Bromley SK, Sumen C, et al. The immunological synapse: a molecular machine controlling T cell activation. Ciencia. 1999;285:2217.

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